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sRNA Annotations

2nd structure
(RNAfold)
sRNAG0010Get Sequence
Gene Name csrB
Synonyms ECK2787;b4408;
Position 2922178.....2922537
Length 360 bp
Strand reverse
Gene Class CsrB RNA
Species Escherichia coli K12 MG1655
Evidence Inferred from direct assay;
Source regulonDB

Genome position Promoter site

Structural RNA alignment
(RNALogo)
Get alignment sequences

Descriptions


    "The CsrB RNA inhibits CsrA-mediated acceleration of glg mRNA degradation (Liu MY,1997). CsrB binding to CsrA appears to interfere with binding of CsrA to glg mRNA, and CsrA acts to decrease glg mRNA stability by interfering with translation of the glg mRNA (Baker CS,2002). The CsrB and CsrC RNAs each inhibit the activity of the CsrA protein (Weilbacher T,2003). The CsrB RNA binds to CsrA protein, forming an RNA-protein complex with 1:18 stoichiometry, respectively (Liu MY,1997). The sequences and locations of the possible CsrA-binding repea.....

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References

Liu MY, Gui G, Wei B, Preston JF, Oakford L, YĆ¼ksel U, Giedroc DP, and Romeo T (1997) "The RNA molecule CsrB binds to the global regulatory protein CsrA and antagonizes its activity in Escherichia coli." J Biol Chem 272 (28)  PubMed
Baker CS, Morozov I, Suzuki K, Romeo T, and Babitzke P (2002) "CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli." Mol Microbiol 44 (6)  PubMed
Jiang GR, Nikolova S, and Clark DP (2001) "Regulation of the ldhA gene, encoding the fermentative lactate dehydrogenase of Escherichia coli." Microbiology 147 (Pt 9)  PubMed
Altier C, Suyemoto M, Ruiz AI, Burnham KD, and Maurer R (2000) "Characterization of two novel regulatory genes affecting Salmonella invasion gene expression." Mol Microbiol 35 (3)  PubMed
Aarons S, Abbas A, Adams C, Fenton A, and O`Gara F (2000) "A regulatory RNA (PrrB RNA) modulates expression of secondary metabolite genes in Pseudomonas fluorescens F113." J Bacteriol 182 (14)  PubMed
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Comparative Genomics by UCSC Genome Browser

Network Visualization

Regulators/sRNAs


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sRNAs/Targets


sRNA Expression Profiles

TitleF plasmid induced changes in expression levels in E. coli
Citation(s)16432259;16981998;SeriesGSE1154
Samples
1:MG1655_replicate12:MG1655_replicate23:MG1655F_replicate1
4:MG1655F_replicate25:DH5alpha_replicate16:DH5alpha_replicate2
7:DH5alphaF_replicate18:DH5alphaF_replicate2
IG_1816_2922136_2922756_rev_st
more

External Database Connections

ECK120002573
EB4282
2847719
ABE-0047213
JWR0062
EG31119
G0-8785
b4408
RF00018


Department of Biological Science and Technology,

Institute of Bioinformatics National Chiao Tung University, Hsinchu, Taiwan

Contact with: bryan@mail.NCTU.edu.tw