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sRNA Annotations

2nd structure
(RNAfold)
sRNAG0021Get Sequence
Gene Name micC
Synonyms ECK1373;tke8;IS063;b4427;
Position 1435145.....1435253
Length 109 bp
Strand forward
Gene Class MicC small RNA
Species Escherichia coli K12 MG1655
Evidence Inferred from direct assay;Inferred from expression pattern;
Source regulonDB

Genome position Promoter site

Structural RNA alignment
(RNALogo)
Get alignment sequences

Descriptions


    "MicC is a small RNA whose expression is induced by growth at low temperature or on minimal media (Chen S,2002. Chen S,2004). Overexpression of MicC causes a 60% reduction of OmpC expression, while deletion of micC causes a 1.5-2 fold increase in OmpC expression. 22 nucleotides at the 5" end of MicC are able to base pair with a sequence located upstream of the ribosome binding site in the ompC mRNA and represses OmpC expression by inhibiting binding of the 30S ribosomal subunit to ompC mRNA (Chen S,2004). Review: (A.....

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References

Chen S, Lesnik EA, Hall TA, Sampath R, Griffey RH, Ecker DJ, and Blyn LB () "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome." Biosystems 65 (2-3)  PubMed
Altuvia S (2004) "Regulatory small RNAs: the key to coordinating global regulatory circuits." J Bacteriol 186 (20)  PubMed
Hershberg R, Altuvia S, and Margalit H (2003) "A survey of small RNA-encoding genes in Escherichia coli." Nucleic Acids Res 31 (7)  PubMed
Chen S, Zhang A, Blyn LB, and Storz G (2004) "MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli." J Bacteriol 186 (20)  PubMed

Comparative Genomics by UCSC Genome Browser

Network Visualization

Regulators/sRNAs


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sRNAs/Targets


sRNA Expression Profiles

TitleF plasmid induced changes in expression levels in E. coli
Citation(s)16432259;16981998;SeriesGSE1154
Samples
1:MG1655_replicate12:MG1655_replicate23:MG1655F_replicate1
4:MG1655F_replicate25:DH5alpha_replicate16:DH5alpha_replicate2
7:DH5alphaF_replicate18:DH5alphaF_replicate2
IG_902_1431011_1441074_fwd_f_st
more

External Database Connections

ECK120002612
2847713
ABE-0047248
JWR0234
EG31144
G0-8901
b4427
RF00121


Department of Biological Science and Technology,

Institute of Bioinformatics National Chiao Tung University, Hsinchu, Taiwan

Contact with: bryan@mail.NCTU.edu.tw