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sRNA Annotations

2nd structure
(RNAfold)
sRNAG0025Get Sequence
Gene Name oxyS
Synonyms ECK3952;b4458;
Position 4156308.....4156417
Length 110 bp
Strand reverse
Gene Class OxyS RNA; oxidative stress regulator
Species Escherichia coli K12 MG1655
Evidence Inferred from direct assay;Inferred from mutant phenotype;
Source regulonDB

Genome position Promoter site

Structural RNA alignment
(RNALogo)
Get alignment sequences

Descriptions


    "OxyS RNA plays a regulatory role in the oxidative stress response (Altuvia S,1997). OxyS RNA activity results in an antimutator effect (Altuvia S,1997). OxyS RNA is involved in regulation of fhlA (Altuvia S,1997), rpoS (Altuvia S,1997. Zhang A,1997. Zhang A,1998), and multiple additional genes (Altuvia S,1997). OxyS also regulates the generation of intracellular H2O (Gonzalez-Flecha B,1999). OxyS RNA interacts with Hfq protein (Zhang A,1998. Zhang A,2002) and OxyS and Hfq together act to inhibit translation of the RpoS mRNA (Zhang A,1998)......

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References

Altuvia S, Weinstein-Fischer D, Zhang A, Postow L, and Storz G (1997) "A small, stable RNA induced by oxidative stress: role as a pleiotropic regulator and antimutator." Cell 90 (1)  PubMed
Zhang A, Altuvia S, and Storz G (1997) "The novel oxyS RNA regulates expression of the sigma s subunit of Escherichia coli RNA polymerase." Nucleic Acids Symp Ser  (36)  PubMed
Gonz├ílez-Flecha B, and Demple B (1999) "Role for the oxyS gene in regulation of intracellular hydrogen peroxide in Escherichia coli." J Bacteriol 181 (12)  PubMed
Argaman L, and Altuvia S (2000) "fhlA repression by OxyS RNA: kissing complex formation at two sites results in a stable antisense-target RNA complex." J Mol Biol 300 (5)  PubMed
Altuvia S, Zhang A, Argaman L, Tiwari A, and Storz G (1998) "The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding." EMBO J 17 (20)  PubMed
more..

Literature Records


Species Conditions Experiment Type Regulation PMID
Escherichia coli a cellular response to oxidative stress and protects against DNAdamage   induce PubMed

Comparative Genomics by UCSC Genome Browser

Network Visualization

Regulators/sRNAs


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sRNAs/Targets


sRNA Expression Profiles

TitleF plasmid induced changes in expression levels in E. coli
Citation(s)16432259;16981998;SeriesGSE1154
Samples
1:MG1655_replicate12:MG1655_replicate23:MG1655F_replicate1
4:MG1655F_replicate25:DH5alpha_replicate16:DH5alpha_replicate2
7:DH5alphaF_replicate18:DH5alphaF_replicate2
IG_2562_4152427_4156968_rev_st
more

External Database Connections

ECK120002558
EB4279
2847701
ABE-0047276
JWR0098
EG31116
EG31116
b4458
RF00035


Department of Biological Science and Technology,

Institute of Bioinformatics National Chiao Tung University, Hsinchu, Taiwan

Contact with: bryan@mail.NCTU.edu.tw