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sRNA Annotations

2nd structure
(RNAfold)
sRNAG0079Get Sequence
Gene Name ffs
Synonyms ECK0449;b0455;
Position 475672.....475785
Length 114 bp
Strand forward
Gene Class 4.5S RNA component of the signal recognition particle (SRP)
Species Escherichia coli K12 MG1655
Evidence Inferred from direct assay
Source regulonDB

Genome position Promoter site

NO conserved alignment determine the structure

Descriptions


    "The 4.5S RNA and Ffh together form the signal recognition particle (SRP) (Ribes V,1990. Poritz MA,1990. Luirink J,1992), which binds to the signal sequence (Luirink J,1992) and targets the nascent protein to the SRP receptor, FtsY, (Miller JD,1994). The SRP is involved in integration of nascent proteins into the membrane (Macfarlane J,1995. de Gier JW,1996. de Gier JW,1998. Koch HG,1999. Tian H,2000). The interaction between 4.5S RNA and Ffh, (Wood H,1992. Lentzen G,1994. Lentzen G,1996. Zheng N,1997. Suzuma S,1999), the GTP-dependent (Mill.....

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References

Koch HG, Hengelage T, Neumann-Haefelin C, MacFarlane J, Hoffschulte HK, Schimz KL, Mechler B, and Müller M (1999) "In vitro studies with purified components reveal signal recognition particle (SRP) and SecA/SecB as constituents of two independent protein-targeting pathways of Escherichia coli." Mol Biol Cell 10 (7)  PubMed
Tian H, Boyd D, and Beckwith J (2000) "A mutant hunt for defects in membrane protein assembly yields mutations affecting the bacterial signal recognition particle and Sec machinery." Proc Natl Acad Sci U S A 97 (9)  PubMed
Wood H, Luirink J, and Tollervey D (1992) "Evolutionary conserved nucleotides within the E.coli 4.5S RNA are required for association with P48 in vitro and for optimal function in vivo." Nucleic Acids Res 20 (22)  PubMed
Lentzen G, Dobberstein B, and Wintermeyer W (1994) "Formation of SRP-like particle induces a conformational change in E. coli 4.5S RNA." FEBS Lett 348 (3)  PubMed
Lentzen G, Moine H, Ehresmann C, Ehresmann B, and Wintermeyer W (1996) "Structure of 4.5S RNA in the signal recognition particle of Escherichia coli as studied by enzymatic and chemical probing." RNA 2 (3)  PubMed
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Network Visualization

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sRNA Expression Profiles

TitleF plasmid induced changes in expression levels in E. coli
Citation(s)16432259;16981998;SeriesGSE1154
Samples
1:MG1655_replicate12:MG1655_replicate23:MG1655F_replicate1
4:MG1655F_replicate25:DH5alpha_replicate16:DH5alpha_replicate2
7:DH5alphaF_replicate18:DH5alphaF_replicate2
ffs_b0455_st
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External Database Connections

ECK120002469
EB4190
944909
ABE-0001579
JWR0009
EG30027
EG30027
b0455
328


Department of Biological Science and Technology,

Institute of Bioinformatics National Chiao Tung University, Hsinchu, Taiwan

Contact with: bryan@mail.NCTU.edu.tw